![]() ![]() Ethanol reduces vigilance-dependent Ca 2+ transients in noradrenergic terminals, but has little effect on astroglial responsiveness to norepinephrine, suggesting that ethanol suppresses their activation by inhibiting norepinephrine release. ![]() Vigilance-dependent astroglial activation is abolished by deletion of α 1A-adrenergic receptor from astroglia, indicating that norepinephrine acts directly on these ubiquitous glial cells. ![]() Using in vivo two-photon imaging, we show that locomotion-induced Ca 2+ elevations in mouse astroglia are profoundly inhibited by ethanol, an effect that can be reversed by enhancing norepinephrine release. The actions of norepinephrine are profoundly altered by recreational drugs like ethanol, but the consequences of these changes on distinct targets such as astrocytes, which exhibit norepinephrine-dependent Ca 2+ elevations during vigilance, are not well understood. Norepinephrine adjusts sensory processing in cortical networks and gates plasticity enabling adaptive behavior. ![]()
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |